Background and aim: Wet Cupping Therapy (WCT) is an ancient therapy which has been worldwide used and being recommended in the Islamic religion. Wet cupping therapy has been proved to be effective in decreasing physical problem related to the hypertension such as pain, headache, yet psychological problem such as anxiety which were indicators of the quality of life. Materials and methods: This study used quasi-experimental approach with pre-posttest control group design. 32 respondents were included in this study chosen by using simple random sampling technique. Instrument used was WHOQOL-BREF which included four domain consists of physical, psychological, social, and environmental with 26 question items. Cupping therapy in this study used Cupping Puncture Cupping (CPC). Data analysis used Wilcoxon and Mann-Whitney. Results: Results showed that there was significant improvement in physical domain of quality of life (p value 0.001), and psychological domain (p value< 0.001), social domain (p value 0.001),
and environmental domain (p value 0.001) after cupping therapy has been applied. Cupping therapy has proven to be effective in improving the quality of life of hypertension patients. Conclusion: Wet cupping therapy (Hijama) was effective in improving all domain of the quality of life in hypertension patients after a month intervention. Finally, this study found that there was a meaningful effect of wet cupping therapy application in improving quality of life of the
hypertension patients. Cupping therapy is suggested to be applied as the complementary therapy for the hypertension patients as follow the prophet hadith.