Decoding Oncogenesis: Molecular Insights Guiding Precision Oncology Strategies

Document Type : Review paper


1 Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran

2 Ege University, Graduate School of Natural and Applied Science, Biology Department


Background and aim: Cancer, a global health challenge, arises from genetic alterations in proto-oncogenes, leading to oncogenes that drive cell growth. Molecular insights in the realm of precision oncology are essential for tackling its complexity.
Methods: In our research, we conducted a comprehensive search across academic databases and online resources, employing key terms such as “oncogenes” and “precision oncology”." This search was conducted on reputable platforms including PubMed, Web of Science, and Google Scholar. Inclusion criteria encompassed peer-reviewed articles in English that focused on oncogenes' molecular aspects and precision oncology. Exclusion criteria consisted of non-English articles, duplicates, conference abstracts, ensuring the selection of pertinent and high-quality research for our review.
Results: Our study extensively examines the role of oncogenes in the context of precision oncology, specifically focusing on their implications for early cancer detection. We elucidate the intricate molecular processes, emphasizing the transition from proto-oncogenes to oncogenes and their significance in precision oncology. Our findings underscore the crucial role of oncogenes in the context of precision diagnosis, prognosis, and targeted treatment strategies, highlighting their potential as key components in advancing precision oncology methodologies.
Conclusion: Comprehensive comprehension of oncogenesis at the molecular level is imperative for early cancer detection and the advancement of precision oncology.


Main Subjects

Volume 2, Issue 2
Special Issue: Abstract and Papers from ICBMS23 (Turkey), ICBM23 (Hungary), ICCMM23 (Italy)
Pages 268-273
  • Receive Date: 19 December 2023
  • Accept Date: 19 December 2023