Overcoming Multidrug Resistance: Molecular Insights into Strategies for Effective Cancer Drug Delivery

Background and aim: Multidrug resistance (MDR) remains an obstacle in cancer treatment. This review paper aims to provide a comprehensive overview of the molecular mechanisms underlying MDR in cancer and to explore innovative strategies for enhancing drug delivery to overcome this challenge. Our goal is to elucidate the latest molecular insights that can inform the development of more effective therapeutic approaches.
Methods: We conducted an extensive literature search using online databases such as PubMed, Web of Science, and Scopus. Key terms included "multidrug resistance," "cancer drug delivery," "molecular mechanisms," and related variations. Articles published from 2015 to 2023 were considered to ensure coverage of recent developments. The inclusion criteria encompassed studies focusing on molecular mechanisms of MDR in cancer, innovative drug delivery strategies, and relevant preclinical and clinical outcomes. We excluded articles that were not available in English.
Results: Our analysis highlights the intricate network of molecular mechanisms contributing to MDR in cancer. We discuss the potential of combination therapies targeting MDR-associated pathways and the promising results of preclinical and clinical studies. Moreover, we present advancements in drug delivery systems that enhance drug stability, circulation time, and selective targeting of cancer cells, thereby mitigating MDR.
Conclusion: Molecular insights into the mechanisms of MDR offer opportunities for the development of targeted therapies that can sensitize drug-resistant cancer cells. Innovative drug delivery systems provide a means to improve drug pharmacokinetics and tumor-specific delivery, enhancing therapeutic efficacy. Combining these approaches holds great promise in the battle against MDR in cancer treatment.