Exploring Oncology Research: From Molecular Discoveries to Translational Breakthroughs

Document Type : Review paper


1 Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

2 Department of Surgical, Oncological and Stomatological Disciplines, Via Divisi 83, 90133 Palermo, Italy


Background and aim: Oncology aims to detect cancer early, provide accurate diagnoses, and implement various treatments. Advances in oncology include mRNA-based therapies, such as cancer vaccines and therapeutics. mRNA vaccines have shown success in generating immunity and have potential for cancer immunotherapy. mRNA-based treatments can target specific tumor antigens or inhibit tumor growth. Ongoing research aims to optimize delivery systems and overcome challenges, with the potential to revolutionize cancer care.
Methods: This literature review used a comprehensive methodology to explore the connection between oncology, molecular research, and mRNA. Through a systematic search of databases and the application of inclusion/exclusion criteria, 35 relevant papers were selected for analysis. Descriptive statistics summarized the papers' characteristics, providing a comprehensive overview of the current understanding of mRNA in oncology and molecular research.
Results: These studies focus on cancer research, emphasizing molecular biology techniques in diagnosis and treatment. They highlight biomarkers, personalized therapies, and advancements in molecular technologies. Some explore glycans and precision medicine challenges for specific cancers. Overall, they contribute to understanding cancer biology and developing effective approaches, showcasing the transformative impact of molecular research in cancer detection and treatment.
Conclusion: In conclusion, this literature review on oncology and molecular research highlights the significant advancements in understanding the role of mRNA in cancer. The selected studies demonstrate the potential of mRNA as a biomarker for early detection, prognosis, and targeted therapy across various cancer types. These findings emphasize the importance of molecular approaches in oncology research and suggest the promising impact of mRNA-based interventions on patient outcomes. Further investigations are needed to explore mRNA dysregulation mechanisms, optimize delivery systems, and conduct clinical trials to evaluate efficacy and safety. These efforts can lead to the development of personalized approaches for cancer prevention, diagnosis, and treatment.


Main Subjects

Volume 2, Issue 2
Special Issue: Abstract and Papers from ICBMS23 (Turkey), ICBM23 (Hungary), ICCMM23 (Italy)
Pages 173-180
  • Receive Date: 19 December 2023
  • Accept Date: 19 December 2023