Document Type : Original paper
Authors
1 Management Committee Member, Global Research, Education, and Event Network (GREEN), Iran
2 Department of Biology, Faculty of Basic Sciences, Hamedan Branch, Islamic Azad University, Hamedan, Iran
3 Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy
4 Department of Biology, Faculty of Basic Sciences, Bu- Ali Sina University, Hamedan, Iran
5 Department of Clinical Biochemistry, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
Abstract
Background and aim: The aim of this study was to Evaluation of the effects of hydroalcoholic extract of raspberry fruit (Rubus fruticosus L.) on the balance of the oxidant-antioxidant system and serum levels of total oxidant status (TOS) in male diabetic rats induced with streptozotocin.
Materials and methods: In this laboratory experimental study Diabetic rats were induced by diabetes induction by IP injection of streptozotocin. Raspberry fruit was extracted with the usual method. Rats were randomly divided into five control, diabetic and diabetic + doses 50, 100, 200 mg / kg. After intraperitoneal injection of raspberry fruit extract for 28 days, the Serum levels of total oxidant status was determined and the data were statically analyzed using ANOVA.
Results: Serum levels of TOS was significantly increased in the diabetic group (P<0.05) and significantly decreased after treatment with the extract (P<0.05).
Conclusion: Raspberry fruit extract with increased antioxidant, and inhibiting the production of Destructive oxidants in the serum level of diabetic rat, increase antioxidant defenses and improve nitric oxide performance.
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