Background and purpose : The synthesis of nanoparticles , especially nanocomposite is of particular importance due to their application in the fields of medicine and industry . Based on this, the present study examines the synthesis of copper oxide hybrid nanocomposite. Material and method : During this experimental-laboratory research , the chemical precipitation method of the composite structure was used for the synthesis of copper oxide-clay hybrid nanocomposite and it was confirmed by using FTIR and XRD . In addition, the morphology of nanoparticles was determined by SEM/TEM measurements. Results : The results of the present study show that the processed nanocomposites were pure and had dimensions of 250-200 nm. Conclusion: Overall, the results of this research showed that the nanocomposite of copper oxide and clay prepared in this research has the nature of a desirable nanoparticle and has desirable dimensions. This nanoparticle can be used in medicine and industry.