AgCl Nanoparticles in vitro Anticancer Effects Against Human Cervical Cancer Cells

Document Type : Original paper

Authors

1 Aldent University, Tirana, Albania

2 Department of Biology, Faculty of Basic Sciences, Damghan Branch, Islamic Azad University, Damghan, Iran

Abstract

Background and aim: Nanoparticles have potential anticancer effects on cancer cells. In vitro and in vivo studies have reported the cytotoxic effects of silver nanoparticles on cancer cells. Despite a number of studies carried out on the anticancer effects of silver nanoparticles on cancer cells, there are few report on the anticancer effects of green synthesized silver nanoparticles on cervical cancer cells. The aim of this study was to determine the cytotoxic effects of green synthesized AgCl on cervical cancer (Hela) cells in vitro. Materials and methods: AgCl nanoparticles were synthesized using Onopordum acanthium extract. HeLa cells were divided into control (no- treated) group and groups treated with 1.5625, 3.125, 6.25, and 12.5µg/ml of AgCl nanoparticles. Cell viability was evaluated using MTT assay method. Results: The results of MTT showed that viability of Hela cells did not significantly change in groups treated with 1.5625 and 3.125 µg/ml of AgCl nanoparticles. However, the Hela cells viability significantly decreased compared to the control group at concentrations ≥ 6.25 µg/ml of AgCl nanoparticles. Conclusion: Our findings revealed that despite lower concentrations of AgCl nanoparticles, higher concentrations had cytotoxic effects on cervical cancer cells in vitro.

Keywords

References

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International Journal of BioLife Sciences (IJBLS)
Volume 1, Issue 3
(Special Issue: papers selected from ICLS22, Istanbul, Turkey)
Pages 182-186

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History

  • Receive Date: 18 September 2022
  • Revise Date: 04 October 2022
  • Accept Date: 12 October 2022

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