The Association between HLADRB1*1501, IL7Ra, and APOE Polymorphism and MS in Iranian Population

Document Type : Original paper

Author

Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

Abstract

Background and aim: Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. Despite many research carried out to find the pathogenesis of this disease, the MS pathogenesis is still unclear. The association of HLA-DRB1*1501 with MS risk has been investigated in many populations. This study aimed to investigate the association of HLADRB1*1501, IL7Ra, and APOE polymorphism genes with MS in patients in Tehran. Materials and methods: The participants in this study were selected from the neurology department of Shariati Hospital in Tehran (30 patients with MS), and 30 healthy blood donors from the Tehran Blood Transfusion Center (control group). Blood samples were obtained and DNA was extracted using the PCR method. The genotype was determined using the sequencing approach. Results: A significant association was identified between these polymorphisms in the patient and control groups in the HLADRB1*1501 gene, G allele (p = 0.000), and in the IL7Ra gene, T allele (p=0.022). However, the PCR results for the APOE gene were unfavorable for sequencing, and the genotype was not determined. Conclusion: The findings of this study revealed that the polymorphism of the 1501*HLADRB1 and IL7Ra genes in the Tehran patient population was similar to the European population.

Keywords

References

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International Journal of BioLife Sciences (IJBLS)
Volume 1, Issue 3
(Special Issue: papers selected from ICLS22, Istanbul, Turkey)
Pages 119-127

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History

  • Receive Date: 06 September 2022
  • Revise Date: 10 September 2022
  • Accept Date: 02 October 2022

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