Antifungal Effects of Solanum Melongena L Peel Extract Against Candida Albicans: In Vitro Study

Document Type : Original paper

Authors

1 Lecturer of the Faculty of Medicine, Department of Physiology, University of Muhammadiyah Makassar, Makassar City, Indonesia.

2 Department of Pediatric, Faculty of Medicine and Health Science, University of Muhammadiyah Makasssar, Makassar city, Indonesia

3 Undergraduate student, Faculty of Medicine and Health Science, University of Muhammadiyah Makasssar, Makassar city, Indonesia

4 Department of Nutrition, Medical Faculty, Gorontalo State University, Gorontalo city, Indonesia,

Abstract

Background and aim: Candida albicans (C. albicans) is a fungus that most commonly causes superficial mucosal infections in humans. If the host is immunosuppressed, C. albicans, which initially lived commensally, will turn into a pathogen and infect the host's body. The increased use of antifungals and side effects of synthetic/chemical drugs have made people turn to herbal medicine. Active compound that can be found in plants that act as an adjuvant therapy, such as Solanum melongena L. This study aims to determine the effectiveness of Purple eggplant peel extract compared with nystatin against the growth inhibition of C. albicans. Materials and methods: The method used well diffusion. Antifungal activity shown of the inhibition zone. Total samples were 25 samples divided into five groups; groups treated with 
Purple Eggplant peel extract 25 %, 50 %, 75%, positive control (nystatin) and negative control. Data was analysed with Kruskal-Wallis test. Results: Purple Eggplant peel extract inhibited C. albicans growth characterized by an inhibition 
zone that formed. Means of diameter of inhibition zone were statistically significant different between groups (p-value = 0.000). Conclusion: Purple Eggplant peel extract with 25%, 50%, and 75% concentration has the same 
ability as nystatin in inhibiting the growth of C. albicans.

Keywords


Volume 1, Issue 2
(Special Issue: papers selected from ICLS20 and ICCBMS21; ICFNEAS21, Istanbul, Turkey)
Pages 89-95
  • Receive Date: 05 June 2021
  • Revise Date: 09 July 2021
  • Accept Date: 23 July 2021