Lecturer of the Faculty of Medicine, Department of Physiology, University of Muhammadiyah Makassar, Makassar City, Indonesia.
Postgraduate Doctoral Candidate of Science of Medicine, Faculty of Medicine, University of Hasanuddin, Makassar City, Indonesia.
Faculty of Medicine, Department of Microbiology, University Muslim Indonesia, Makassar City, Indonesia.
Nursing Department, Faculty of sport and health, State University of Gorontalo, Gorontalo City, Indonesia.
Biochemistry Department, Faculty of Medicine, University of Hasanuddin, Makassar City, Indonesia.
Immunology and Microbiology Department, Faculty of Medicine, University of Hasanuddin, Makassar City, Indonesia.
Background and aim: Curcumin has an antimicrobial effect, presumably due to its ability to bind vitamin D receptors (VDR). This study aimed to investigate the curcumin effects in inducing VDR and inhibiting of Salmonella typhi growth in vivo. Materials and methods: Mice were divided into: group I (curcumin 200 mg/kg/bw), group II (curcumin 400 mg/kg b.w), positive control and negative control. The intervention was carried out for 5 days. After the fifth day, mice were maintained for 3 weeks to determine the amount of colony growth in the post-intervention period and examination of level VDR in serum. Results: In group with curcumin 200 mg/kg/bw there was a decreased in average number of colonies of 23.60 CFU/ml (p<0.001). The decline in the average number of colonies was also present in the intervention group with curcumin 400 mg/kg/bw at 17.20 CFU/ml (p<0.000). Serum levels of VDR significantly increased five days after treatment with curcumin (200 and 400 mg/kg bw) p<0.018 and p<0.002, respectively). Conclusion: Curcumin (200 and 400 mg/kg/bw) significantly increases serum levels of vitamin D receptors and inhibit the growth of S. Typhi colony. Antimicrobial component curcumin as a potential agent in adjuvant therapy for increasing immunity as well as a therapeutic alternative other than antibiotics in treating typhoid fever.