TY - JOUR ID - 162033 TI - Application of CRISPR/Cas9 in Breast Cancer Treatment: A Mini Review JO - International Journal of BioLife Sciences (IJBLS) JA - IJBLS LA - en SN - AU - Tabaku, Mirela AU - Amini, Nooshin AU - Rostami Motamed, Hadis AD - Pediatric Department, University Hospital "Mother Teresa", Tirana, Albania AD - Management Committee Member, Global Research, Education, and Event Network (GREEN) Y1 - 2022 PY - 2022 VL - 1 IS - Issue 3 SP - 104 EP - 113 KW - Human acellular amniotic membrane KW - wound healing KW - diabetic rat DO - 10.22034/jbs.2022.162033 N2 - Breast cancer is the commonest cause of cancer death in women worldwide. Although impressive gains in breast cancer research and treatment have been made over the past decades, breast cancer treatment still remains a significant global challenge. Recently, application of gene editing tools, such as the CRISPR/Cas9 system, has shown a clinical potential to discover novel targets for cancer therapy. CRISPR is a family of DNA sequences found in the genomes of prokaryotic organisms. Cas9 is an enzyme that uses CRISPR sequences as a guide to recognize and cleave specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR/Cas9 that is a genome editing tool used to edit parts of the genome. CRISPR/Cas9 could be a major step forward to cancer management by providing patients with an effective method for dealing with cancers by dissecting the carcinogenesis pathways, identifying new biologic targets, and perhaps arming cancer cells with drugs. Moreover, CRISPR/Cas9 can be employed to rapidly engineer immune cells for cancer immunotherapeutic applications. The CRISPR/Cas9 system has been reported to play an important role in preventing drug resistance in breast cancer. It has also been used to develop early breast cancer diagnostic tools and treatments. Despite the potential of CRISPR/Cas9 in breast cancer treatment, some challenges remain to be solved for clinical application of this system in breast cancer treatment. This review aims to present the application of CRISPR/Cas9 in breast cancer treatment. UR - https://www.jobiost.com/article_162033.html L1 - https://www.jobiost.com/article_162033_b5c5d345604305c340d5ae0b37cb0d5d.pdf ER -