%0 Journal Article %T Therapeutic Potential of Silver Nanoparticles Biosynthesized Using Aqueous Extract of Citrus Sinensis Peel on Acetic Acid-Induced Ulcerative Colitis in Male Wistar Rats %J International Journal of BioLife Sciences (IJBLS) %I Parnam Publication Co. %Z 2821-1642 %A Ige, Serah Funke %A Adeloye, Adeniyi Ayokunle %A Anifowose, Peace Esther %A Akinola, Olajumoke Badirat %A Badmus, Jelili A %D 2022 %\ 10/01/2022 %V 1 %N 4 %P 202-219 %! Therapeutic Potential of Silver Nanoparticles Biosynthesized Using Aqueous Extract of Citrus Sinensis Peel on Acetic Acid-Induced Ulcerative Colitis in Male Wistar Rats %K Ulcerative colitis %K inflammatory disease %K Silver nanoparticle %K Citrus sinensis peel %K Antioxidant %K anti-inflammatory %R 10.22034/jbs.2023.365343.1000 %X Ulcerative colitis is an inflammatory disease, and antioxidants with anti-inflammatory effects of silver nanoparticles have been explored. This study investigates the therapeutic potential of silver nanoparticles bio-fabricated using aqueous extract of Citrus sinensis peel (CsPEx-AgNPs) on ulcerative colitis in male Wistar rats. Thirty adult male Wistar rats were assigned into; Non-Colitis Control, Colitis control, Colitis+CsPEx (Citrus sinensis Peel Extract, 250µg/Kg), Colitis+AgNO3 (250µg/kg), Colitis+CsPEx-AgNPs (25µg/Kg) and Colitis+CsPEx-AgNPs (250µg/Kg) groups. Colitis was induced with a single intra-rectal administration of 6% acetic acid (1mL/100g B.W.), followed by oral administration of regimens in groups 3-6 for seven days. Eighth-day post-colitis induction, rats were sacrificed; blood and colon were collected for haematological, biochemical, and histopathological examination. Data were analyzed using one-way ANOVA followed by Tukey’s post-hoc test for multiple comparisons. The colitis control group showed: reduced body weight, increased colonic weight and thickness, diarrhoea and macroscopic scores, a significant decrease in packed cell volume, a significant increase in Platelet count, plateletcrit, red cell distribution width, depleted superoxide dismutase, glutathione, catalase levels and elevated concentrations of malondialdehyde, myeloperoxidase and tumour necrosis factor-α, mucosal ulceration, infiltration of inflammatory cells in the mucosa and submucosa. Treatment with CsPEx-AgNPs increased body weight, reduced colonic weight and thickness, diarrhoea, and macroscopic scores; improved red blood cell and platelet indices; enhanced superoxide dismutase, glutathione, catalase levels and reduced the concentrations of malondialdehyde, myeloperoxidase and tumour necrosis factor-α; reduced cellular infiltrates and restored mucosal epithelial layer. CsPEx-AgNPs have an anti-colitic effect and may provide therapeutic potential for the treatment of ulcerative colitis. %U https://www.jobiost.com/article_167837_6fc0be12cda845d736eca2ab7aff340a.pdf